Secretome is biological material containing metabolites secreted by cells during the culture process. These metabolites include various growth factors and cytokines that are useful in regenerating damaged cells or tissues. Umbilical Cord Secretome ProSTEM (USEPro) is a secretome processed and produced by ProSTEM, derived from UC-MSC donors that have undergone a rigorous screening process in accordance with BPOM standards, ISO 9001, and Indonesian Ministry of Health Regulations No. 48 and 50 of 2012.
ProSTEM ensures the safety and effectiveness of our products by manufacturing USEPro in laboratories that meet standards Good Manufacturing Practices (GMP). Examples of USEPro variants produced by ProSTEM include USEPro with antibiotics and USEPro without antibioticsBoth are safe to use; however, the antibiotic-free variant can be given to patients with allergies to antibiotics.
Benefits:
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Secretome shows promising results by influencing four key phases of the healing process: hemostasis, inflammation, proliferation, and remodeling [1].
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Secretome can be used to treat degenerative diseases such as diabetic wound [1], pimple [2], osteoartritis [3], and other conditions.
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The secretome consists of soluble factors (growth factors, cytokines, chemokines, and hormones) as well as insoluble factor contained in extracellular vesicles (EVs) [4].
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Secretome is also considered a candidate for cancer therapy because it has the intrinsic ability to migrate to the tumor network [4].
Refrences :
- Rado-Yupanqui, J.W.; RamÃrez-Orrego, L.; Cortez, D.; Vera-Ponce, V.J.; Chenet, S.M.; Tejedo, J.R.; Tapia-Limonchi, R. The Hidden Power of the Secretome: Therapeutic Potential on Wound Healing and Cell-Free Regenerative Medicine—A Systematic Review. Int. J. Mol. Sci. 2025, 26, 1926.
- Arifka, M., Wilar, G., Elamin, K. M., & Wathoni, N. (2022). Polymeric Hydrogels as Mesenchymal Stem Cell Secretome Delivery System in Biomedical Applications. Polymers, 14(6), 1218.
- Ewari, G. A. P., & Aryana, I. G. N. W. (2024). The use of mesenchymal stem cell secretome in osteoarthritis: A literature review.
- International Journal of Research and Review, 11(6), 359–370.
- MartÃn-Noguerol, T., Talenti, F., Paul, J., Gómez-GarcÃa, E., Steinbach, L., & Luna, A. (2024). Artificial intelligence in musculoskeletal radiology: Current status and future directions. European Journal of Radiology, 178, 110640.
