Karsinoma nasofaring (KNF) It is a type of malignancy caused by the Epstein-Barr virus (EBV), genetic mutations, and exposure to carcinogenic substances, which leads to abnormal growth of the nasopharyngeal epithelial layer (Adham et al., 2012). Indonesia is the second country to report the highest number of nasopharyngeal carcinoma cases in the world after China. The standard treatment for nasopharyngeal carcinoma is chemoradiotherapy. However, chemoradiotherapy has a high level of toxicity, which can cause serious side effects. Patients’ responses to chemoradiotherapy can be categorized as complete or incomplete responses. Incomplete responses include partial responses, stable disease, and progressive (progressive diseases). Patients with incomplete responses require adjuvant therapy in the form of additional chemoradiotherapy to achieve a complete response and improve survival rates. However, the administration of additional chemoradiotherapy often negatively affects the patient’s general condition, leading to a drastic reduction in food and fluid intake, weight loss, and decreased function of body organs such as kidney and liver function, as well as bone marrow suppression (Myelosuppressive) as well as a decline in the patient’s quality of life. Based on existing research and references, dendritic cells and dendritic cell secretomes can enhance cellular immunity, which is expected to help inhibit the progression of nasopharyngeal carcinoma.
Currently, ProSTEM, together with Dr. A. Budi Sulistya, Sp.THT-KL(K)., M.A.R.S., is conducting recruitment for a clinical trial titled Safety and Efficacy of Autologous Dendritic Cells (DC-Auto) and the Combination of Autologous Dendritic Cells (DC-Auto) with Allogeneic Dendritic Cell Secretome (DC-Allo) as Adjuvant Therapy in Patients with Nasopharyngeal Carcinoma with Partial Response and Stable Disease" at Gatot Soebroto Army Central Hospital, Central Jakarta, with ethical approval letter number: 27/VII/KEPK/2022.
Refrences :
1 Adham M, Kurniawan AN, Muhtadi AI, Roezin A, Hermani B, Gondhowiardjo S, et al. Nasopharyngeal carcinoma in indonesia: Epidemiology, incidence, signs, and symptoms at presentation. Chin J Cancer. 2012;31(4):185–96.
